Sulbutiamine Capsules | 200mg | 60 Count
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Ingredient List: Sulbutiamine Powder, Maltodextrin (excipient), Vegetable Cellulose (capsules), Silicon Dioxide (excipient), Magnesium Stearate (excipient)
Sulbutiamine is a molecule which is two Thiamine (B1) molecules bound together, similar to how Pyritinol is two Pyridoxine (B6) molecules bound together. Sulbutiamine is known as isobutyryl thiamine disulfide and sometimes referred to by its Brand Names of Ereon or Arcalion; it is most commonly used for Asthenia, or weakness (part neurological and part myopathic) as well as treatment of somatic and psychic inhibition. It is said to not possess psychostimulant properties, although it is designed to act centrally (in the brain). Sulbutiamine is synthesized from Thiamine, where after opening of the thiazole ring of Thiamine and dimerisation to a disulfide compound it is then esterified.
In a model of BALB/c mice 14-16 weeks of age, 10 days of 300mg/kg sulbutiamine by oral gavage with 5% gum acacia appeared to improve memory (assessed by operant task); this study noted that there were no differences between groups in acquisition but there were significant differences in retention which resulted in increased performance.
Study: Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain.
Study: Determination of sulbutiamine and its disulfide derivatives in human plasma by HPLC using on-line post-column reactors and fluorimetric detection
Study: Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation.
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Statements & Warnings
† These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.
Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s). Always consult with a qualified health physician before taking any new dietary supplement.
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