Coluracetam Powder

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MPN:
72075
  • Coluracetam Powder
  • Coluracetam Powder
$17.99 - $65.49

Description

coluracetam.jpg

Notice: This product is sold as a nootropic compound. Any usage is based on your own research, please consider all warnings and recommendations before completing purchase. By purchasing this product, you agree to potential risks associated with this particular ingredients and our terms & conditions.

 
Ingredient List: Coluracetam Powder

Coluracetam (full structural name of 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro2,3-b quinolin-4-yl)acetoamide and codenames of MKC-231 or BCI-540) is a racetam compound formulated as a nootropic for the purpose of cognitive enhancement.

A known metabolite is hydroxylated coluracetam on the 2-carbon of the pyrrolidinone backbone, it is sometimes referred to as M-MKC-231.[2] It appears inactive on the main mechanism of action coluracetam is known for (increasing HACU).[2]

 

High affinity choline uptake (HACU) is the uptake of choline at the synapse for the purpose of acetylcholine synthesis, and is seen as a rate-limiting step of acetylcholine synthesis. Coluracetam appears to associated with these transporters.[2]

Study: MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake. [2]

Abstract - MKC-231, a putative cholinergic activity, is reported to improve learning and memory impaired in AF64A-treated animals. MKC-231 enhances high-affinity choline uptake (HACU) known as the rate-limiting step of acetylcholine (ACh) synthesis. We investigated the mode of action (MOA) of HACU enhancement by MKC-231. Intracerebroventricular (i.c.v.) injections of AF64A (3 nmol/brain) resulted in significant HACU reduction in hippocampal synaptosomes. Treatment with MKC-231 increased Vmax of HACU and Bmax of [3H]-HC-3 binding 1.6 and 1.7-fold, respectively. In studies of [3H]-MKC-231 binding and Biacore analysis, MKC-231 showed noticeable affinity for cloned high-affinity choline transporters (CHT1). The present study suggests that MKC-231 directly affects trafficking of CHT1 and increases the numbers of transporter, working for HACU, at the synaptic membrane.[2]

Citation & Resources:
1.https://examine.com/supplements/coluracetam

2.https://www.ncbi.nlm.nih.gov/pubmed/18461273

Toxicity & Measurement Guidelines

Measurements:

Transfer unit is ~5mg per leveled scoop.

Toxicity:

"The racetams possess a very low toxicity and lack serious side effects."[1]

References & Citations:

1. Piracetam and other structurally related nootropics. https://www.ncbi.nlm.nih.gov/pubmed/8061686

Statements & Warnings

These statements have not been evaluated by the Food & Drug Administration. This product is not approved by the FDA. This product is not intended to diagnose, treat, cure or prevent any diseases.

WARNING: 
Keep out of the reach of children. Do not take this or any other compound if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s). Always consult with a qualified health physician before taking any new compound.

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